These are the figures and table for the supplementary materials demonstrating that Cortrosyn worked.
| Nestling Corticosterone | Adult Corticosterone | |||||
|---|---|---|---|---|---|---|
| Predictors | Estimates | CI | p | Estimates | CI | p |
| Intercept (Baseline) | 4.64 | -1.01 – 10.29 | 0.107 | 1.72 | -3.70 – 7.15 | 0.534 |
| Timepoint 2 | 24.36 | 18.42 – 30.31 | <0.001 | 13.18 | 5.74 – 20.63 | 0.001 |
| Timepoint 3 | 18.53 | 12.68 – 24.39 | <0.001 | 19.51 | 12.06 – 26.96 | <0.001 |
| Cortrosyn at Baseline | -1.05 | -8.09 – 5.98 | 0.769 | 0.70 | -6.98 – 8.37 | 0.859 |
| Cortrosyn at Timepoint 2 | 12.92 | 4.75 – 21.09 | 0.002 | -2.80 | -13.33 – 7.73 | 0.602 |
| Cortrosyn at Timepoint 3 | 27.28 | 19.18 – 35.39 | <0.001 | 30.28 | 19.75 – 40.81 | <0.001 |
| Random Effects | ||||||
| σ2 | 83.22 | 64.98 | ||||
| τ00 | 37.12 band | 3.98 band | ||||
| 14.54 unit_box | ||||||
| ICC | 0.38 | 0.06 | ||||
| N | 43 band | 18 band | ||||
| 9 unit_box | ||||||
| Observations | 122 | 54 | ||||
| Marginal R2 / Conditional R2 | 0.686 / 0.807 | 0.809 / 0.820 | ||||
| Adult Corticosterone | Adult Glucose | Nestling Corticosterone | Nestling Glucose | |||||
|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | CI | Estimates | CI | Estimates | CI | Estimates | CI |
| (Intercept) | 4.55 | 3.05 – 6.05 | 213.14 | 210.19 – 216.09 | 6.40 | 3.83 – 8.96 | 204.52 | 194.48 – 214.56 |
| timepointinduce | 25.80 | 24.42 – 27.19 | 30.71 | 27.27 – 34.16 | 18.72 | 16.31 – 21.12 | 17.82 | 10.35 – 25.28 |
| timepointdex | 8.97 | 7.54 – 10.41 | 30.02 | 23.10 – 36.94 | -0.81 | -3.24 – 1.62 | 15.64 | 8.18 – 23.11 |
| timepointacth | 37.26 | 33.21 – 41.30 | 61.19 | 51.28 – 71.10 | 22.79 | 20.27 – 25.30 | 14.00 | 6.28 – 21.71 |
| sexM | 3.33 | 1.14 – 5.52 | -7.20 | -13.43 – -0.96 | ||||
| as.factor(year)2017 | -1.64 | -3.60 – 0.33 | ||||||
| as.factor(year)2018 | -0.18 | -2.12 – 1.76 | ||||||
| as.factor(year)2019 | -0.10 | -2.00 – 1.79 | ||||||
| ICC | 0.09 | 0.16 | 0.40 | |||||
| N | 327 band | 331 band | 43 nest | 43 nest | ||||
| 187 band | 187 band | |||||||
| Observations | 1933 | 1509 | 697 | 698 | ||||
| Marginal R2 / Conditional R2 | 0.424 / 0.474 | 0.193 / 0.324 | 0.451 / NA | 0.023 / 0.412 | ||||
| Baseline Glucose | Induced - Base Glucose | Induced - Post-Dex Glucose | Post-Cortrosyn - Induced Glucose | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p |
| Intercept | 213.25 | 211.02 – 215.47 | <0.001 | 34.74 | 30.76 – 38.71 | <0.001 | -3.04 | -11.39 – 5.30 | 0.475 | 13.42 | 4.68 – 22.17 | 0.003 |
| Corticosterone | 1.88 | -0.15 – 3.91 | 0.070 | 0.77 | -2.89 – 4.44 | 0.679 | 1.33 | -6.39 – 9.04 | 0.736 | -6.04 | -14.89 – 2.80 | 0.175 |
| Mass | -1.04 | -7.82 – 5.74 | 0.763 | -14.58 | -25.47 – -3.70 | 0.009 | 12.52 | -1.57 – 26.61 | 0.082 | |||
| Sex (male) | 1.44 | -1.86 – 4.73 | 0.393 | |||||||||
| Corticosterone * Mass | 4.34 | 0.69 – 8.00 | 0.020 | |||||||||
| ICC | 0.04 | 0.13 | 0.39 | |||||||||
| N | 325 band | 318 band | 98 band | |||||||||
| Observations | 767 | 568 | 102 | 45 | ||||||||
| Marginal R2 / Conditional R2 | 0.004 / 0.040 | 0.027 / 0.156 | 0.030 / 0.407 | 0.042 / 0.020 | ||||||||
| Baseline Glucose | Induced - Base Glucose | Induced - Post-Dex Glucose | Post-Cortrosyn - Induced Glucose | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p |
| Intercept | 204.81 | 193.74 – 215.87 | <0.001 | 17.45 | 11.08 – 23.81 | <0.001 | -2.25 | -8.91 – 4.40 | 0.507 | -4.24 | -19.17 – 10.68 | 0.577 |
| Corticosterone | -6.48 | -13.02 – 0.07 | 0.052 | -5.52 | -10.95 – -0.09 | 0.046 | 1.42 | -4.49 – 7.33 | 0.638 | -4.05 | -14.90 – 6.81 | 0.465 |
| Mass | -2.79 | -9.35 – 3.78 | 0.406 | 5.57 | -0.19 – 11.33 | 0.058 | 2.07 | -4.24 – 8.38 | 0.521 | 9.14 | -3.43 – 21.71 | 0.154 |
| ICC | 0.59 | 0.16 | 0.14 | 0.38 | ||||||||
| N | 43 nest | 41 nest | 41 nest | 39 nest | ||||||||
| Observations | 182 | 172 | 170 | 151 | ||||||||
| Marginal R2 / Conditional R2 | 0.021 / 0.599 | 0.047 / 0.200 | 0.005 / 0.143 | 0.025 / 0.392 | ||||||||
| AK Base Glucose | NY Base Glucose | TN Base Glucose | WY Base Glucose | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p |
| Intercept | 204.76 | 199.38 – 210.15 | <0.001 | 213.40 | 211.10 – 215.70 | <0.001 | 207.34 | 201.27 – 213.40 | <0.001 | 199.42 | 194.51 – 204.32 | <0.001 |
| Base Corticosterone | 2.29 | -2.61 – 7.19 | 0.359 | 1.50 | -0.69 – 3.70 | 0.180 | -2.38 | -8.98 – 4.21 | 0.479 | -3.25 | -8.95 – 2.46 | 0.265 |
| Mass | -3.80 | -8.73 – 1.13 | 0.131 | -2.99 | -5.19 – -0.78 | 0.008 | -1.54 | -7.04 – 3.96 | 0.583 | -5.18 | -10.04 – -0.31 | 0.037 |
| Corticosterone * Mass | -2.46 | -7.18 – 2.27 | 0.308 | 1.16 | -1.17 – 3.50 | 0.330 | 2.56 | -3.91 – 9.03 | 0.439 | 0.15 | -6.64 – 6.94 | 0.965 |
| ICC | 0.19 | 0.04 | 0.24 | 0.19 | ||||||||
| N | 71 band | 251 band | 74 band | 112 band | ||||||||
| Observations | 115 | 684 | 113 | 164 | ||||||||
| Marginal R2 / Conditional R2 | 0.039 / 0.218 | 0.015 / 0.054 | 0.022 / 0.256 | 0.036 / 0.220 | ||||||||
| AK Induced - Base Glucose | NY Induced - Base Glucose | TN Induced - Base Glucose | WY Induced - Base Glucose | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predictors | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p | Estimates | CI | p |
| Intercept | 38.03 | 29.76 – 46.30 | <0.001 | 34.68 | 30.71 – 38.65 | <0.001 | 29.44 | 22.40 – 36.48 | <0.001 | 48.35 | 39.90 – 56.80 | <0.001 |
| Induced - Base Corticosterone | -1.55 | -10.07 – 6.96 | 0.721 | 0.62 | -3.18 – 4.42 | 0.749 | 0.76 | -6.68 – 8.20 | 0.839 | 1.61 | -6.69 – 9.91 | 0.702 |
| Mass | -0.69 | -8.45 – 7.08 | 0.862 | 0.43 | -3.04 – 3.90 | 0.809 | 1.83 | -5.01 – 8.67 | 0.596 | 2.78 | -5.27 – 10.82 | 0.496 |
| Corticosterone * Mass | 4.58 | -4.60 – 13.76 | 0.328 | 3.98 | 0.07 – 7.89 | 0.046 | -5.87 | -12.23 – 0.49 | 0.070 | 3.60 | -3.47 – 10.68 | 0.315 |
| ICC | 0.08 | 0.13 | ||||||||||
| N | 69 band | 250 band | ||||||||||
| Observations | 95 | 500 | 91 | 119 | ||||||||
| Marginal R2 / Conditional R2 | 0.016 / 0.099 | 0.008 / 0.139 | 0.042 / 0.009 | 0.014 / -0.011 | ||||||||